We study how neural circuit activity underlies circadian rhythms, sleep and memory using Drosophila, molecular genetics, electrophysiology, optogenetics and computational neuroscience. We are interested in the fundamental biology of these behaviours and how they evolved. We are also interested in how circadian rhythms, sleep and memory are affected by ageing, drugs and diseases including Alzheimer’s, Parkinson’s, Down’s, schizophrenia, neuropathies and epilepsy (using human brain tissue). We collaborate with clinicians and Industry to study these diseases and test novel drugs. Related to food security we study the effect of neonicotinoid insecticides on fly and bee circadian rhythms and sleep.